GDP-L-fucose disodium salt

CAS: 148296-47-3

Ref. 3D-MG01912

Product Information

• Name: GDP-L-fucose disodium salt
• Synonyms: Guanosine 5'-diphospho-b-L-fucose disodium salt
• Brand: Biosynth
• Description: GDP-L-fucose is a natural fucosyl donor and substrate for fucosyltransferases (FUT) that catalyses the fucosylation of, for example, human milk oligosaccharides or glycoproteins. GDP-L-fucose is widely used in (chemo)enzymatic synthesis of glycans. Cymit Quimicaesis of GDP-L-fucose, a nucleotide sugar consisting of an L-fucose that is β-glycosidically linked to the nucleotide guanosine diphosphate (GDP), is achieved either through de novo synthesis via GDP-mannose or through a salvage pathway from free fucose. Fucosylation is catalysed by fucosyltransferases (~ 13 FUT genes have been identified in the human genome to date) to generate α-1,2, α-1,3, α-1-4 and α-1-6 linkages of fucose to other sugars, as well as direct linkages to peptides, with release of GDP (Lairson, 2008).

Chemical properties

• Molecular weight: 633.31 g/mol
• Formula: C₁₆H₂₃N₅O₁₅P₂Na₂
• Purity: Min. 90 Area-%
• Color/Form: White Off-White Powder