GDP-L-fucose diammonium salt

CAS: 15839-70-0

Ref. 3D-MG07459

Product Information

• Name: GDP-L-fucose diammonium salt
• Synonyms: 6-Deoxy-Β-L-Galactopyranosylguanosine 5'-Diphosphate, Fucopyranose, 1→5′-ester with guanosine 5′-(trihydrogen pyrophosphate), GDP-<span class="text-smallcaps">L</span>-fucose, GDP-β-<span class="text-smallcaps">L</span>-Fucose, Gdp-Fucose, Guanosine 5'-Diphospho-B-L-Fucose*Sodium Approx. 90, Guanosine 5'-Diphospho-Fucose, Guanosine 5'-Diphospho-Β-L-Fucose Sodium Salt, Guanosine 5′-(trihydrogen diphosphate), P′-(6-deoxy-β-<span class="text-smallcaps">L</span>-galactopyranosyl) ester, Guanosine 5′-(trihydrogen pyrophosphate), mono(6-deoxy-<span class="text-smallcaps">L</span>-galactopyranosyl) ester, Guanosine 5′-(trihydrogen pyrophosphate), mono(6-deoxy-β-<span class="text-smallcaps">L</span>-galactopyranosyl) ester, Guanosine 5′-(trihydrogen pyrophosphate), mono(6-deoxygalactopyranosyl) ester, Guanosine 5′-(trihydrogen pyrophosphate), mono-<span class="text-smallcaps">L</span>-fucosyl ester, Guanosine 5′-diphosphate <span class="text-smallcaps">L</span>-fucose, Guanosine 5′-pyrophosphate, <span class="text-smallcaps">L</span>-fucosyl ester, Guanosine 5′-pyrophosphate, β-<span class="text-smallcaps">L</span>-fucopyranosyl ester, Guanosine diphosphate fucose, Guanosine diphosphofucose, Guanosine pyrophosphate, <span class="text-smallcaps">L</span>-fucosyl ester, Guanosine-5'-Diphosphate-Beta-L-Fucose, 2Na, [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3R,4S,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name), [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name), [5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl 3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)

Description

GDP-L-fucose diammonium salt is a synthetase inhibitor that has been shown to inhibit the synthesis of GDP-L-fucose. This compound is also known as 5,6-dichloro-1,2,3,4-tetrahydroisoquinoline and is a secondary metabolite of the bacterium Aerobacter aerogenes. The enzyme kinetic assay was used to determine the inhibition constant for this compound. It has been shown to be active against E. coli K-12 and S. subtilis in cell culture experiments. Inhibition of GDP-L-fucose synthesis by this compound leads to reduced bacterial growth, which may be due to its interference with cell surface carbohydrate attachment or its effects on other metabolic pathways such as glycolysis and nucleotide synthesis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 623.41 g/mol
• Formula: C₁₅H₂₃N₅O₁₅P₂·N₂H₈
• Purity: Min. 95%