Glucosyl-C18-sphingosine

CAS: 52050-17-6

Ref. 3D-MG23669

Product Information

• Name: Glucosyl-C18-sphingosine
• Synonyms: Glucosylsphingosine2-Amino-3-hydroxy-4-octadecenyl b-D-glucopyranoside(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecenyl b-D-glucopyranoside Glucosylsphingosine - synthetic, (2S,3R,4E)-2-Amino-3-hydroxy-4-octadecen-1-yl β-<span class="text-smallcaps">D</span>-glucopyranoside, (3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl beta-D-mannopyranoside, Glucosyl psychosine, Glucosyl sphingosine, Glucosyl-C₁₈-sphingosine, Glucosylsphingosine, Sphingosyl beta-glucoside, beta-D-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, (R-(R*,S*-(E)))-, β-<span class="text-smallcaps">D</span>-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl, β-<span class="text-smallcaps">D</span>-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl, β-<span class="text-smallcaps">D</span>-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, [R-[R*,S*-(E)]]-

Description

Glucosyl-C18-sphingosine is a sphingolipid that has been shown to inhibit the activity of Gaucher's enzyme, which is responsible for the synthesis of glucosylceramide. It has been demonstrated in a model system that glucosyl-C18-sphingosine inhibits mitochondrial membrane potential and decreases ATP levels, leading to cell death. The molecular pathogenesis of Gaucher disease is not well understood but it is believed to be related to defective lysosomal function. Glucosyl-C18-sphingosine may be used as a diagnostic agent for Gaucher disease and other metabolic disorders involving glucosylceramide accumulation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 461.63 g/mol
• Formula: C₂₄H₄₇NO₇
• Purity: Min. 95%
• Color/Form: Powder