Product Information
AT-56 is a novel and well-tolerated drug that is used for the treatment of cancer. AT-56 has been shown to inhibit the activity of mineralocorticoid receptor (MR), which is a member of steroid hormone receptors. The MR regulates salt and water balance in the body, so inhibition of this receptor can lead to severe hypertension. AT-56 also has an antiangiogenic effect by inhibiting vascular endothelial growth factor (VEGF) production in endothelial cells. This leads to decreased choroidal neovascularization, which causes blindness due to damage to retinal pigment epithelium cells. AT-56 also induces cell lysis, which may be associated with its ability to induce apoptosis in cancer cells.
AT-56 binds to the tumor cell membrane with a high affinity and increases permeability through ion channels, leading to cell lysis and death.
Chemical properties
Technical inquiry about: 3D-MGA64098 AT-56
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