1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide ammonium salt
CAS: 132929-88-5
Ref. 3D-MH07437
| 1mg | 575.00 € | ||
| 2mg | 1,018.00 € | ||
| 5mg | 2,136.00 € | ||
| 10mg | 3,682.00 € |
Product Information
- (3R,5S)-1-Methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
- (3R,5S)-1-methyl-2-oxo-5-(pyridin-3-yl)pyrrolidin-3-yl beta-D-glucopyranosiduronic acid
- 1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide
- trans-3'-Hydroxycotinine O--D-glucuronide
- trans-3′-Hydroxycotinine-O-glucuronide
- β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, (3R,5S)-1-methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl
- β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 1-methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl, (3R-trans)-
- β-D-Glucopyranosiduronic acid, 1-methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl, (3R-trans)-
- (3R,5S)-1-Methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl β-D-glucopyranosiduronic acid
- β-D-Glucopyranosiduronic acid, (3R,5S)-1-methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl
- See more synonyms
The glucuronidation of 1-O-(trans-3-hydroxycotinine)-b-D-glucuronide ammonium salt is mediated by the enzyme UDP-glucuronosyltransferase. This reaction is catalyzed by the transfer of a glucuronic acid residue from UDP-glucuronic acid to a hydroxyl group on the side chain of 1-O-(trans-3-hydroxycotinine)-b-D-glucuronide ammonium salt. The kinetic analysis of human urine samples has shown that this reaction is significant. This metabolite can be detected in urine samples using next generation sequencing and its concentration can be used as an indicator for the consumption of tobacco or nicotine containing products. Epidemiological studies have shown that this metabolite has significant effects on cancer risk. Genotyping and genotype studies have shown that this metabolite is responsible for genetic polymorphisms that are associated with increased cancer risk.
Chemical properties
Technical inquiry about: 3D-MH07437 1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide ammonium salt
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