5-(2-Hydroxyethyl)-2'-deoxyuridine
CAS: 90301-60-3
Ref. 3D-MH16752
| 5mg | 189.00 € | ||
| 10mg | 272.00 € | ||
| 25mg | 399.00 € | ||
| 50mg | 568.00 € | ||
| 100mg | 879.00 € |
Product Information
- 2'-Deoxy-5-(2-hydroxyethyl)uridine
5-(2-Hydroxyethyl)-2'-deoxyuridine is a regiospecific inhibitor of the enzyme thymidylate synthase. This drug inhibits the synthesis of thymine and uracil, which are used in DNA replication. 5-(2-Hydroxyethyl)-2'-deoxyuridine binds to the carbon chain of uracil, preventing its incorporation into DNA. 5-(2-Hydroxyethyl)-2'-deoxyuridine has been shown to be an effective inhibitor of thymidylate synthase in both prokaryotic and eukaryotic cells. The mechanism of action is thought to be competitive inhibition with respect to substrate binding at the active site of the enzyme. 5-(2-Hydroxyethyl)-2'-deoxyuridine can be synthesized by reacting acrylonitrile with 5-iodouridine chloride, followed by elimination reactions with methylene chloride or thionyl chloride. The product can then be
Chemical properties
Technical inquiry about: 3D-MH16752 5-(2-Hydroxyethyl)-2'-deoxyuridine
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