Z-VAD-FMK

CAS: 187389-52-2

Ref. 3D-MHA38952

Product Information

• Name: Z-VAD-FMK
• Synonyms: 13: PN: WO2005039629 PAGE: 18 claimed protein, 3: PN: WO2011028611 SEQID: 3 unclaimed protein, <span class="text-smallcaps">L</smallcap>-Alaninamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, N-[(Benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]-L-alaninamide, N-[(Phenylmethoxy)Carbonyl]-L-Valyl-N-[(1S)-3-Fluoro-1-(2-Methoxy-2-Oxoethyl)-2-Oxopropyl]-L-Alaninamide, N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-<smallcap>L</span>-alaninamide, Z-VAD(OMe)-FMK, Z-Val-Ala-Asp(OMe)-FMK, z-VAD-FMK, 3: PN: WO0158526 SEQID: 3 claimed sequence

Description

Z-VAD-FMK is a caspase inhibitor that blocks the activation of caspases. It inhibits IL-2 receptor and prevents apoptosis by blocking the nuclear DNA from entering the cell nucleus. Z-VAD-FMK has been shown to inhibit the death of HL60 cells in a model system. It has also been shown to have inhibitory properties against cyclin D2, which is an important factor in the apoptosis pathway. This drug may be used to treat conditions such as leukemia, psoriasis, and arthritis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 467.49 g/mol
• Formula: C₂₂H₃₀FN₃O₇
• Purity: Min. 95%