5-Keto-D-gluconic acid

CAS: 5287-64-9

Ref. 3D-MK14117

Product Information

• Name: 5-Keto-D-gluconic acid
• Synonyms: D-Xylo-5-Hexulosonic acid5-Oxo-5-deoxy-D-gluconic acid

Description

5-Keto-D-gluconic acid is an intermediate in the synthetic pathway of glucose. The enzyme 5-keto-D-gluconate dehydrogenase catalyzes the conversion of 5-keto-D-gluconate to D-glucono-1,5-lactone. This reaction is important for plant physiology and is used industrially for the production of citric acid. In order to synthesize 5-keto-D-gluconic acid, a p. pastoris strain was engineered with an increased expression of 5KGDH, which led to an increase in the production of this compound. This synthesis took place through a dinucleotide phosphate intermediate that was formed by two molecules of malonic acid. Citric acid was also synthesized from this intermediate.
The enzyme activity levels were measured using a bacterial strain that contained a wild type gene sequence (WT) and a mutant gene sequence (

• Brand: Biosynth

Chemical properties

• Molecular weight: 194.14 g/mol
• Formula: C₆H₁₀O₇
• Purity: Min. 98 Area-%
• Color/Form: Clear Liquid
• InChI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h3-5,7,9-11H,1H2,(H,12,13)/t3-,4+,5-/m1/s1
• InChI key: InChIKey=IZSRJDGCGRAUAR-MROZADKFSA-N
• SMILES: O=C(CO)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O