Product Information
- Pump-1 Substrate
- Mmp-7 Substrate, Fluorogenic
- 360 Mmp Fret Substrate V
- Matrilysin Substrate
- Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser
- Dnp-Rplalwrs
The enzyme DNP-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser (DAPPLE) is a zymogen that is activated by proteolytic cleavage to form an active enzyme. DAPPLE has been shown to cause neuronal death in vitro. The enzyme can be inhibited by the addition of specific inhibitors, such as 4-(2-aminoethyl)benzenesulfonyl fluoride, which blocks the activity of matrix metalloproteinases. DAPPLE has been found in mammalian ovaries and induces the release of growth factors when it is activated by proteolytic cleavage. The optimum pH for DAPPLE activity is 7.5 and it can be inhibited by the addition of certain drugs, such as phenylmethylsulfonyl fluoride or sodium azide.
Chemical properties
Technical inquiry about: 3D-MMP-3072-PI Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH
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