Product Information
Alofanib is a potent inhibitor of CDK4/6, which inhibits the phosphorylation of Rb and the release of E2F1. It also inhibits the phosphorylation of secretase, leading to reduced production of amyloid-beta peptides and suppression of tumor growth. Alofanib has been shown to inhibit tumor growth in animals with adrenocortical carcinoma and urothelial carcinoma. It has been studied in clinical trials for patients with cancer. The effective dose determined in mice was 0.5 mg/kg/day, but it is not yet known what the effective dose will be in humans.
Chemical properties
Technical inquiry about: 3D-MPC88866 Alofanib
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