Product Information
- all-trans-Retinyl b-glucuronide
- Retinyl beta-glucuronide
- beta-D-Glucopyranosiduronic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenyl, (all-E)-
- (2S,3S,4S,5R,6R)-6-{[(2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl]oxy}-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (non-preferred name)
E-Retinyl b-glucuronide is a metabolite of vitamin A that is formed in the liver by glucuronidation of retinol. It has been shown to have immunomodulatory effects and can be used to activate various immune cells, such as T lymphocytes, monocytes, and natural killer cells. E-Retinyl b-glucuronide binds to cell surface antigens and induces the expression of surface markers on mononuclear cells. In vitro studies have shown that this metabolite has growth-promoting activity for certain types of cancerous cells including colon carcinoma, breast carcinoma, and thyroid carcinoma. E-Retinyl b-glucuronide is also known to inhibit the binding of 13-cis retinoic acid to its receptor, thereby preventing the activation of genes in target tissues.
Chemical properties
Technical inquiry about: 3D-MR146410 E-Retinyl b-glucuronide
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