Product Information
- 2-Carboxyphenyl b-D-glucopyranosiduronic acid
- 2-Carboxyphenyl β-D-glucopyranosiduronic acid
- Glucopyranosiduronic acid, o-carboxyphenyl, β-D-
- β-D-Glucopyranosiduronic acid, o-carboxyphenyl
- Salicyl phenolic glucuronide
- β-D-Glucopyranosiduronic acid, 2-carboxyphenyl
Salicylic acid D-glucuronide is the major metabolite of aspirin, which is formed by hydrolysis of acetylsalicylic acid. It has been demonstrated to have anti-inflammatory and analgesic effects. Salicylic acid D-glucuronide is excreted in urine and can be detected in human serum. The formation rate of this metabolite varies with the individual's age, sex, and kidney function.
Salicylic acid D-glucuronide can be formed in vitro using hydrochloric acid and acetylsalicylic acid as substrates. This reaction is catalyzed by the enzyme uridine diphosphate glucuronyltransferase (UGT). Salicylic acid D-glucuronide has been shown to form covalent adducts with hydroxyl groups from other molecules in vivo and in vitro, including proteins (e.g., albumin) and DNA bases (e.g.,
Chemical properties
Technical inquiry about: 3D-MS09950 Salicylic acid D-glucuronide
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