Sertraline carbamoyl glucuronide

CAS: 119733-44-7

Ref. 3D-MS16854

Product Information

• Name: Sertraline carbamoyl glucuronide
• Synonyms: (1S-cis)-1-[[4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenyl]methycarbamate]-b-D-glucopyranuronic acidSertraline carbamoyl -O-glucuronide
• Brand: Biosynth
• Description: Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is used primarily in the treatment of depression and anxiety. It inhibits the serotonin transporter protein, making more serotonin available for binding to postsynaptic receptors. Sertraline also has a minor inhibitory effect on norepinephrine and dopamine reuptake, but its primary function is as a selective serotonin reuptake inhibitor. The major metabolite of sertraline is sertraline carbamoyl glucuronide, which is formed through glucuronidation by UGT2B7. This metabolite has been found to be bifurcated with one half being excreted in urine and the other half being excreted in faeces. The half that undergoes urinary excretion has been shown to have a half-life of 24 hours whereas the other half has a much shorter half-life of 2 hours. Carbamoylation of sertraline may

Chemical properties

• Molecular weight: 526.36 g/mol
• Formula: C₂₄H₂₅Cl₂NO₈
• Purity: Min. 95%