SN-38 glucuronide

CAS: 121080-63-5

Ref. 3D-MS16856

Product Information

• Name: SN-38 glucuronide
• Synonyms: 7-Ethyl-10-hydroxy-camptothecin-10-O-b-Dglucuronide(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7] indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid
• Brand: Biosynth
• Description: SN-38 glucuronide is a metabolite of irinotecan that inhibits the growth of cancer cells by binding to the DNA polymerase, blocking the synthesis of DNA. SN-38 glucuronide has potent antitumor activity and high values for inhibiting tumor metastasis. It is mainly excreted in urine as a conjugate with glucuronic acid, which may be why urine samples are often used to measure its concentration. SN-38 glucuronide also interacts with other drugs, including chemical inhibitors and ATP-binding cassette transporters, which can affect its pharmacological properties.

Chemical properties

• Molecular weight: 568.53 g/mol
• Formula: C₂₈H₂₈N₂O₁₁
• Purity: Min. 97.5 Area-%
• Color/Form: Powder