1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose

CAS: 188783-78-0

Ref. 3D-MT15919

Product Information

• Name: 1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose
• Synonyms: Peracetylated 2-fluoro 2-deoxy-L-fucose
• Brand: Biosynth
• Description: Peracetylated 2-fluoro-L-fucose is the acetylated form of 2-deoxy-2-fluoro-L-fucose which is a potent inhibitor of protein fucosylation. It exhibits improved cell permeability and is rapidly deacetylated into its active form, inside the cell. It is metabolised inside the cell into a corresponding donor substrate analogue of GDP-fucose or GDP-2FF, via the salvage pathway. GDP-2FF accumulates in the cell causing a shutdown of de novo pathway which leads to the desired fucosylation inhibition. The addition of 100 uM peracetylated-2-fluoro-L-fucose to plants severely inhibits root growth by 95% compared to an untreated plant, and is more potent compared to 2-fluoro-L-fucose. The material is soluble in DMSO at 10mg/ml.

Chemical properties

• Molecular weight: 292.26 g/mol
• Formula: C₁₂H₁₇FO₇
• Purity: Min. 97 Area-%
• Color/Form: White Off-White Powder