Product Information
Name:Tri-β-GalNAc-6-aminohexanoate
Synonyms:
- Tris-GalNAc-(CH2)6-NH2Triantennary β-GalNAc 6-aminohexanoateTri-β-GalNAc-6-ACATris-GalNAc-Ahx-NH2Tris-β-GalNAc-6-aminohexanoi c acid
Brand:Biosynth
Description:Tri-b-GalNAc-6-aminohexanoate is a synthetic ligand designed to target the asialoglycoprotein receptor (ASGPR) on hepatocytes. The three terminal beta-N-acetylgalactosamine (GalNAc) sugars provide an efficient ASGPR binding. It serves as a platform for lysosomal targeting chimera (LYTAC) development, allowing for the creation of chimeras that specifically target unwanted proteins for degradation within hepatocytes. In addition, tri-b-GalNAc-6-aminohexanoate facilitates the delivery of therapeutic cargo, such as RNA or Cas9 complexes, directly to hepatocytes via ASGPR-mediated endocytosis. This approach is promising for gene therapy and RNAi applications in the liver due to the specificity of ASGPR targeting and the versatility of the conjugation moiety.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,528.74 g/mol
Formula:C67H121N11O28
Purity:Min. 95 Area-%
Technical inquiry about: Tri-β-GalNAc-6-aminohexanoate
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