Product Information
- Triantennary β-D-GalNAc azideTriantennary β-D-GalNAc N3Tris-GalNAc-PEG3-N3tri-beta-GalNAc-PEG3-azidetri-beta-GalNAc-PEG3-N3Tris -β-GalNAc-PEG3-azide tri-β-GalNAc-PEG3-N3(β-D-GalNAc)3-PEG3-N3(β-D-GalNAc-sp)3-NHC(O)-PEG3-N3
Tri-GalNAc-PEG3-azide is an ASGPR-targeted ligand. This molecule contains three beta-GalNAc sugar units (trivalent) linked by a discrete and uniform PEG3 spacer. The spacer terminates with a reactive azide group for conjugation to other molecules. Upon binding to ASGPR, tri-GalNAc-PEG3-azide conjugates are efficiently taken up by cells (endocytosis) due to the trivalent GalNAc recognition. This property allows researchers to deliver various cargo, like RNA or Cas9 complexes, specifically to liver cells (hepatocytes) and permits using tri-GalNAc-PEG3-Azide to create targeted drug delivery systems (LYTACs) or labeled with dyes for imaging tissues.
Chemical properties
Technical inquiry about: 3D-MT184238 Tri-b-GalNAc-PEG3-azide
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