Tri-b-GalNAcAc3-C12-amido-C3-azide

Ref. 3D-MT184243

Product Information

• Name: Tri-b-GalNAcAc3-C12-amido-C3-azide
• Synonyms: Tris-GalNAc-β-C12-azide (perac)Trebler GalNAc azide (peracetylated)3-azidopropylamino-C12-tris-beta-GalNAc-peracetylated3-azidopr opylamino-C12-tris-beta-GalNAc (perAc)3-azido-propylamino-C12-tris-beta-GalNAc-PERAC
• Brand: Biosynth
• Description: This is the peracetylated equivalent of tri-b-GalNAc-C12-amido-C3-azide. This unique bifunctional ligand for ASGPR-targeted applications contains three terminal GalNAc sugars that bind to ASGPR receptors and permit hepatocyte uptake, the C12-amide linker offers a stable spacer and the C3-azide moiety enables tailored bioconjugation via CuAAC click chemistry. This design has the potential for targeted delivery of therapeutic cargo (drugs, siRNA, nanoparticles) to hepatocytes, development of LYTACs for selective protein degradation, and creation of in vivo ASGPR imaging probes.

Chemical properties

• Molecular weight: 2,088.3 g/mol
• Formula: C₉₄H₁₅₄N₁₄O₃₈
• Purity: Min. 95%