Tri-b-GalNAc-gly-C6-DBCO
Ref. 3D-MT184245
| 1mg | 473.00 € | ||
| 5mg | 1,416.00 € |
Product Information
- Tris-β-GalNAc-Gly-DBCOTrebler GalNAc DBCODBCO-Gly-tris-beta-GalNAc
Tri-b-GalNAc-Gly-C6-DBCO is used for targeted siRNA therapies for liver diseases. This synthetic molecule boasts three terminal beta-N-acetylgalactosamine (GalNAc) sugars (tri-antennary GalNAc) enabling high-affinity binding to the asialoglycoprotein receptor (ASGPR) on hepatocyte surfaces. This specific recognition promotes efficient cellular uptake of these cluster conjugates via ASGPR-mediated endocytosis. Crucially, the presence of a C6 spacer and a dibenzoeylcyclooctynone (DBCO) group allows for the attachment of siRNA molecules through bioorthogonal click chemistry. This versatile approach facilitates the development of targeted siRNA conjugates that can be delivered specifically to hepatocytes for RNA interference (RNAi) applications in the liver.
Chemical properties
Technical inquiry about: 3D-MT184245 Tri-b-GalNAc-gly-C6-DBCO
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