Tri-b-GalNAc-b-alanine-NH2
Ref. 3D-MT184248
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Product Information
- Tri-beta-GalNAc-Ala-amineTris-GalNAc-β-Ala-NH2Tris-β-GalNAc-β-Ala-amineTriantennary β-D-GalNAc-β-Alanine-NH2Triantennary β-D-Gal NAc-β-Alanine-Amine
Tri-b-GalNAc-b-alanine-NH2 boasts three terminal beta-N-acetylgalactosamine (GalNAc) sugars, mimicking natural ligands for efficient binding to Ashwell-Morell receptors (C-type lectin of ASGPR) on hepatocytes. The beta-alanine linker connects the GalNAc unit to a terminal amino group (NH2), a key conjugation site for attaching various therapeutic molecules via amide bond formation. This design validates tri-b-GalNAc-b-alanine-NH2 as a valuable tool in medicinal chemistry for developing liver-specific drug delivery systems, allowing researchers to exploit this ligand to create targeted conjugates, like drug-GalNAc conjugates, for specific delivery of therapeutics directly to hepatocytes, potentially improving treatment efficacy and reducing side effects.
Chemical properties
Technical inquiry about: 3D-MT184248 Tri-b-GalNAc-b-alanine-NH2
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