Tri-b-GalNAc-b-alanine-PEG3-azide
Ref. 3D-MT184251
| 1mg | 1,044.00 € | ||
| 10mg | 2,667.00 € |
Product Information
- Tris-GalNAc-β-Ala-PEG3-N3Tris-beta-GalNAc-beta-Ala-PEG3-N3(β-D-GalNAc)3-β-Ala-PEG3-N3Tris-β-GalNAc-β-Ala-PEG3-azideTris-β-GalNAc -β-Alanine-PEG3-azideTriantennary-β-GalNAc-β-Alanine-PEG3-azide
This molecule leverages three terminal beta-GalNAc (N-acetylgalactosamine) sugars for efficient binding to asialoglycoprotein receptors (ASGPR) expressed on liver cells (hepatocytes). The presence of the linker (beta-alanine) and the spacer (PEG3) influences the pharmacokinetics of the conjugate. The key functional group is the terminal azide, which allows for conjugation to various payloads containing alkyne groups and facilitates the development of targeted conjugates for hepatocyte delivery. Upon binding to ASGPR, tri-b-GalNAc-b-alanine-PEG3-azide conjugates are rapidly taken up by hepatocytes via endocytosis, enabling researchers to deliver therapeutic cargo (drugs, siRNA) specifically to the liver.
Chemical properties
Technical inquiry about: 3D-MT184251 Tri-b-GalNAc-b-alanine-PEG3-azide
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