Tri-b-GalNAc-b-alanine-PEG3-maleimide

Ref. 3D-MT184254

Product Information

• Name: Tri-b-GalNAc-b-alanine-PEG3-maleimide
• Synonyms: Tris-β-D-GalNAc-β-Ala-PEG3-MALTriantennary β-D-GalNAc-β-Ala-PEG3-MALTri-β-D-GalNAc-β-Ala-PEG3-MAL(β-D-GalNAc)3-β-Ala-PEG3-Maleimi de
• Brand: Biosynth
• Description: Tri-b-GalNAc-b-Ala-PEG3-MAL contains three terminal beta-N-acetylgalactosamine (GalNAc) sugars arranged in a trivalent configuration, facilitating high-affinity binding to the asialoglycoprotein receptor (ASGPR) expressed on hepatocyte surfaces. The crucial functional group is a terminal maleimide (MAL) moiety, enabling chemoselective bioconjugation with biomolecules harboring thiol (-SH) groups. This strategy allows for site-specific conjugation under mild conditions, valuable for developing targeted conjugates in disciplines like targeted drug delivery and antibody-drug conjugate (ADC) development for hepatocellular carcinoma.

Chemical properties

• Molecular weight: 1,841.01 g/mol
• Formula: C₈₀H₁₃₇N₁₃O₃₅
• Purity: Min. 95%