Tri-b-GalNAc-b-alanine-PEG3-maleimide
Ref. 3D-MT184254
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Product Information
- Tris-β-D-GalNAc-β-Ala-PEG3-MALTriantennary β-D-GalNAc-β-Ala-PEG3-MALTri-β-D-GalNAc-β-Ala-PEG3-MAL(β-D-GalNAc)3-β-Ala-PEG3-Maleimi de
Tri-b-GalNAc-b-Ala-PEG3-MAL contains three terminal beta-N-acetylgalactosamine (GalNAc) sugars arranged in a trivalent configuration, facilitating high-affinity binding to the asialoglycoprotein receptor (ASGPR) expressed on hepatocyte surfaces. The crucial functional group is a terminal maleimide (MAL) moiety, enabling chemoselective bioconjugation with biomolecules harboring thiol (-SH) groups. This strategy allows for site-specific conjugation under mild conditions, valuable for developing targeted conjugates in disciplines like targeted drug delivery and antibody-drug conjugate (ADC) development for hepatocellular carcinoma.
Chemical properties
Technical inquiry about: 3D-MT184254 Tri-b-GalNAc-b-alanine-PEG3-maleimide
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