5-Azacytidine

CAS: 320-67-2

Ref. 3D-NA02947

Product Information

• Name: 5-Azacytidine
• Synonyms: Azacitidine, 5-AzaCVidazaCC-486, 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-, 2-(β-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-on, 2-(β-D-ribofurannosyl)-4-amino-1,3,5-triazine-2-one, 2-(β-D-ribofuranosil)-4-amino-1,3,5-triazin-2-ona, 2-(β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2-one, 4-Amino-1-Beta-D-Ribofuranosyl-S-Triazin-2(1H)-On, 4-Amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,3,5-triazin-2(1H)-one, 4-amino-1-D-lyxofuranosyl-1,3,5-triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one, 4-amino-1-pentofuranosyl-1,3,5-triazin-2(1H)-one, 5 Azc, 5-Ac, 5-Azac, 5-Azacitidine, 5-Azcr, 5-Triazin-2(1H)-One,4-Amino-1-Beta-D-Ribofuranosyl-3, Antibiotic u 18496, Antibioticu18496, Azacytidine, Cc 486, Ladakamycin, Ledakamycin, Mylosar, Nci-C01569, Nsc 103-627, Nsc-102816, U 18496, U18496, Vidaza, Wr 183027, s-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, s-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-, 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Description

An azanucleoside and epigenetic modulator that interferes with nucleic acid metabolism. The compound gets incorporated into RNA and inhibits ribonucleotide reductase subunit RRM2 in leukemia cell lines. Intracellularly, 5-azacytidine can get converted into 2′-deoxy-5-azacytidine (decitabine) and subsequently incorporated in DNA, where it irreversibly inhibits DNMT1 methyltransferase. In human epithelial cell lines, this compound decreases Src-activated expression of a histone chaperone CAF1 and inhibits cell motility and invasiveness.

• Brand: Biosynth

Chemical properties

• Molecular weight: 244.21 g/mol
• Formula: C₈H₁₂N₄O₅
• Purity: Min. 95%
• Color/Form: White Off-White Powder