5'-O-Acetyl-2',3'-O-isopropylideneadenosine
CAS: 15888-38-7
Ref. 3D-NA04029
| 1g | To inquire | ||
| 2g | To inquire | ||
| 5g | To inquire |
Product Information
- 5'-O-Acetyl-2',3'-O-isopropylidene-D-adenosine
- 2′,3′-O-Isopropylidene-5′-O-acetyladenosine
- 5'-O-acetyl-2',3'-O-(1-methylethylidene)adenosine
- 5-Acetyl-2,3-Isopropylenadenosine
- 5′-Acetyl-2′,3′-isopropylideneadenosine
- 5′-O-Acetyl-2′,3′-O-isopropylideneadenosine
- 9-[5-O-acetyl-2,3-O-(1-methylethylidene)pentofuranosyl]-9H-purin-6-amine
- Adenosine, 2′,3′-O-(1-methylethylidene)-, 5′-acetate
- Adenosine, 2′,3′-O-isopropylidene-, 5′-acetate
- Furo[3,4-d]-1,3-dioxole, adenosine deriv.
- See more synonyms
- NSC 90373
5'-O-Acetyl-2',3'-O-isopropylideneadenosine is an anti-leishmanial agent that is synthesized from 2,3-O-isopropylideneadenosine by acetylating the 5' hydroxyl group. It was found to be more potent than the parent compound and other related compounds in inhibiting Leishmania amazonensis promastigotes. The proposed mechanism of action of 5'-O-acetyl-2',3'-O-isopropylideneadenosine involves hydrogen bonding with the guanosine moiety of DNA and inhibition of RNA synthesis. This drug also has an effect on carbonyl oxygens and resonances, which are observed in the nmr spectra. The synthetic scheme for this drug starts with uridine, which is converted to cytidine by reacting it with sodium cyanide in aqueous solution at 0°C. Cytidine
Chemical properties
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