2,3'-Anhydrothymidine

CAS: 15981-92-7

Ref. 3D-NA04576

Product Information

• Name: 2,3'-Anhydrothymidine
• Synonyms: Cyclothymidine2,3'-Anhydro-D-thymidine, 2,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-, 2,3'-O-Cyclothymidine, 2,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, AHT, Anhydrothymidine, Nsc 144601, O2,3'-Cyclothymidine, 3-(hydroxymethyl)-8-methyl-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one, (2R,3R,5R)-3-(hydroxymethyl)-8-methyl-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one, (2S,3R,5R)-3-(hydroxymethyl)-8-methyl-2,3-dihydro-9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one, Anhydro-T

Description

2,3'-Anhydrothymidine is a piperidine-containing nucleoside analog that inhibits the replication of HIV and other viruses. It is structurally related to acyclovir, but has an increased resistance to viral inactivation by acyclovir-resistant strains. 2,3'-Anhydrothymidine binds to the ribose sugar of the viral nucleic acid and prevents the formation of a covalent bond between the 5' hydroxyl group of ribose and the 3' phosphate group. It also inhibits protein synthesis by interfering with the incorporation of amino acids into proteins. 2,3'-Anhydrothymidine has been shown to be effective against human immunodeficiency virus type 1 (HIV-1) in animal models and clinical studies.

• Brand: Biosynth

Chemical properties

• Molecular weight: 224.21 g/mol
• Formula: C₁₀H₁₂N₂O₄
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C10H12N2O4/c1-5-3-12-8-2-6(7(4-13)15-8)16-10(12)11-9(5)14/h3,6-8,13H,2,4H2,1H3
• InChI key: InChIKey=JCSNHEYOIASGKU-UHFFFAOYSA-N
• SMILES: Cc1cn2c(nc1=O)OC1CC2OC1CO