Allopurinol riboside

CAS: 16220-07-8

Ref. 3D-NA07960

Product Information

• Name: Allopurinol riboside
• Synonyms: 1-b-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4-one, 1,5-Dihydro-1-beta-D-ribofuranosyl-4H-pyrazolo(3,4-d)pyrimidin-4-one, 1,5-Dihydro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-4H-pyrazolo[3,4-d]pyrimidin-4-one, 1-(beta-D-ribofuranosyl)-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 1-(beta-L-ribofuranosyl)-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 1-[(2S,3S,4R,5R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl]-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (non-preferred name), 1-pentofuranosyl-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 4-Hydroxy(3,4-d)pyrazolopyrimidine riboside, 4-Hydroxy-1beta-D-ribofuranosylpyrazolo(3,4-d)pyrimidine, 4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-1-beta-D-ribofuranosyl-, 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, Allopurinol ribonucleoside, Allopurinol-1-ribonucleoside, NSC 252629, Nsc 138437
• CAS: 16220-07-8

Description

Allopurinol riboside is a hydroxyl analog of allopurinol. Allopurinol riboside has minimal toxicity in tissue culture and exhibits no cytotoxicity in human serum. It is a potent inhibitor of microbial infection, including infections caused by Hepatitis C virus (HCV), Leishmania amazonensis, and Mycobacterium tuberculosis. Allopurinol riboside binds to adenine nucleotide and inhibits the synthesis of purines, which are necessary for DNA replication. This binding also inhibits the production of ATP, leading to cell death. In addition, allopurinol riboside inhibits the growth of human macrophages in vitro by inhibiting protein synthesis. Allopurinol riboside may be useful for treating HCV-induced liver disease or leishmaniasis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 268.23 g/mol
• Formula: C₁₀H₁₂N₄O₅
• Purity: Min. 97 Area-%
• Color/Form: White Powder