Alloxan hydrate

CAS: 3237-50-1

Ref. 3D-NA71089

Product Information

• Name: Alloxan hydrate
• Synonyms: Mesoxalylurea5,6-Dioxyuracil2,4,5,6-Tetraoxypyrimidine, 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-dihydroxy-, 5-24-09-00382 (Beilstein Handbook Reference), 5,5-Dihydroxy-2,4,6(1H,3H,5H)-pyrimidinetrione, 2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate, NSC 221304, 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate, 5,5-Dihydroxybarbituric acid, 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-dihydroxy-, 5,5-dihydroxypyrimidine-2,4,6(1H,3H,5H)-trione, BRN 0155548, Alloxan monohydrate, Alloxan hydrate, 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-dihydroxy- (9CI), 5,5-Dihydroxyperhydropyrimidinetrione, Alloxan monohydrate, CCRIS 5957, Barbituric acid, 5,5-dihydroxy-, 5,5-Dihydroxy-2,4,6(1H,3H,5H)-pyrimidinetrione

Description

A pyrimidine derivative, widely used for the induction of diabetes in experimental animals. It preferentially accumulates in pancreatic β cells in Langerhans islets via glucose transporter GLUT2. In the presence of intracellular thiols such as glutathione, it gets involved in a cyclic redox reaction with its reduction product, dialuric acid. This triggers the production of toxic levels of reactive oxygen species (ROS) and directs the cells in necrosis. Alloxan also inhibits glucokinase, which regulates glucose-induced insulin secretion.

• Brand: Biosynth

Chemical properties

• Molecular weight: 142.07 g/mol
• Formula: C₄H₂N₂O₄•xH₂O
• Purity: Min. 95%