Alloxan hydrate
CAS:
Ref. 3D-NA71089
1kg
1,366.00€
2kg
2,078.00€
100g
255.00€
250g
430.00€
500g
1,047.00€
Product Information
Name:Alloxan hydrate
Synonyms:
- Mesoxalylurea5,6-Dioxyuracil2,4,5,6-Tetraoxypyrimidine
Brand:Biosynth
Description:A pyrimidine derivative, widely used for the induction of diabetes in experimental animals. It preferentially accumulates in pancreatic β cells in Langerhans islets via glucose transporter GLUT2. In the presence of intracellular thiols such as glutathione, it gets involved in a cyclic redox reaction with its reduction product, dialuric acid. This triggers the production of toxic levels of reactive oxygen species (ROS) and directs the cells in necrosis. Alloxan also inhibits glucokinase, which regulates glucose-induced insulin secretion.
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Chemical properties
Molecular weight:142.07 g/mol
Formula:C4H2N2O4•xH2O
Purity:Min. 95%
Technical inquiry about: Alloxan hydrate
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