5-Bromo-2'-deoxyuridine

CAS: 59-14-3

Ref. 3D-NB06315

Product Information

• Name: 5-Bromo-2'-deoxyuridine
• Synonyms: 2'-Deoxy-5-bromouridine5-Bromo-2'-deoxy-D-uridine, (+)-5-Bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione, 2'-Deoxy-5-Bromorouridine, 2'-Deoxy-5-Bromouridine, 5'-Bromodeoxyuridine, 5-Bdu, 5-Brdu, 5-Bromo Deoxyuridine, 5-Bromo-1-(2-Deoxy-Beta-D-Ribofuranosyl)Uracil, 5-Bromo-2'-Desoxyuridine, 5-Bromodesoxyuridine, 5-Bromouracil deoxyriboside, 5-Bromouracil-2-deoxyriboside, 5-bromo-1-(2-deoxypentofuranosyl)pyrimidine-2,4(1H,3H)-dione, BRDU，5-Bromo-2-deoxyuridine, BUdR, BrdUrd, Brdu, Bromodeoxyuridine, Broxuridin, Broxuridina, Broxuridine, Brudr, Nsc 38297, Uridine, 5-bromo-2'-deoxy-

Description

5-Bromo-2'-deoxyuridine (5-BrDU) is a nitrate reductase inhibitor that prevents the reduction of nitrate to nitrite by inhibiting the enzyme nitrate reductase. It is a genotoxic agent that has been shown to cause DNA damage and cell death in vitro. 5-BrDU has been shown to induce preconditioning in vivo, reducing neuronal injury after ischemia. This drug also binds to NMDA receptors and may be useful as a model system for studying neurodegenerative diseases such as Alzheimer's disease. 5-BrDU has been shown to inhibit the polymerase chain reaction in wild-type strains of bacteria, but not in strains with a mutation in their DNA gyrase genes.

• Brand: Biosynth

Chemical properties

• Molecular weight: 307.1 g/mol
• Formula: C₉H₁₁BrN₂O₅
• Purity: Min. 99 Area-%
• Color/Form: White Off-White Powder