8-Bromoadenosine 3',5'-cyclic monophosphate

CAS: 23583-48-4

Ref. 3D-NB07972

Product Information

• Name: 8-Bromoadenosine 3',5'-cyclic monophosphate
• Synonyms: 8-Bromo-D-adenosine 3',5'-cyclic monophosphate, (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, 23583-48-4, 3',5'-(Hidrogenofosfato) Ciclico De 8-Bromoadenosina, 3',5'-(Hydrogenophosphate) Cyclique De 8-Bromoadenosine, 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv., 6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, 8-Bromadenosin-cyclisch-3',5'-(hydrogenphosphat), 8-Bromo-cAMP, 8-Bromo-cyclic 3',5'-AMP, 8-Bromo-cyclic 3′,5′-AMP, 8-Bromoadenosine Cyclic 3',5'-(Hydrogen Phosphate), 8-Bromoadenosine cyclic 3',5'-monophosphate, 8-Bromoadenosine cyclic 3',5'-phosphate, 8-Bromoadenosine cyclic 3′,5′-monophosphate, 8-Bromoadenosine cyclic 3′,5′-phosphate, 8-Bromoadenosine-cAMP, Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), Adenosine, 8-bromo-, cyclic 3′,5′-(hydrogen phosphate), Cyclic 8-bromoadenosine 3',5'-monophosphate, Cyclic 8-bromoadenosine 3′,5′-monophosphate, Nsc 171719

Description

8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cyclic nucleotide that is involved in the regulation of energy metabolism. It is a pharmacological agent that regulates the intracellular levels of cAMP and plays an important role in regulating cell proliferation, differentiation, and survival. 8-Br-cAMP binds to specific protein kinases and alters their activity. It also inhibits the enzymatic activity of DNA polymerase II. 8-Br-cAMP has been shown to inhibit tumor growth in mice with bone cancer. The mechanism by which this drug exerts its antitumor effect appears to be related to increased expression of basic proteins and decreased expression of phosphatase 2A, leading to increased activation of protein kinase A. 8-Br-cAMP also causes cellular accumulation of Ca2+ ions by stimulating an increase in the activity of phospholipase C, which hydrolyzes phosphat

• Brand: Biosynth

Chemical properties

• Molecular weight: 408.11 g/mol
• Formula: C₁₀H₁₁BrN₅O₆P
• Purity: Min. 98 Area-%
• Color/Form: Beige Powder