5'-O-tert-Butyldimethylsilylthymidine

CAS: 40733-28-6

Ref. 3D-NB08945

Product Information

• Name: 5'-O-tert-Butyldimethylsilylthymidine
• Synonyms: 5'-O-tert-Butyldimethylsilyl-D-thymidine, 1-Piperazinecarboxylic Acid, 4-(5-Carboxy-2-Pyridinyl)-, 1-(1,1-Dimethylethyl) Ester, 1-[(2S,4R,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione, 5′-O-(tert-Butyldimethylsilyl)deoxythymidine, 5′-O-[(1,1-Dimethylethyl)dimethylsilyl]thymidine, 5′-O-tert-Butyldimethylsilylthymidine, 6-(4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-piperazinyl)nicotinic acid, 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinic acid, Thymidine, 5′-O-[(1,1-dimethylethyl)dimethylsilyl]-

Description

5'-O-tert-Butyldimethylsilylthymidine is a nucleoside that is used for the synthesis of oligoribonucleotides. It can be prepared by treating 5'-O-tert-butyldimethylsilylthymidine with alkyl bromides in the presence of microwaves and catalytic amounts of a base such as sodium methoxide. The product is purified by vacuum distillation or column chromatography and can be hydrolyzed to uridine, which has been shown to have anti-inflammatory properties. 5'-O-tert-Butyldimethylsilylthymidine can also be converted into deoxyribose through the use of ultrasound.

• Brand: Biosynth

Chemical properties

• Molecular weight: 356.5 g/mol
• Formula: C₁₆H₂₈N₂O₅Si
• Purity: Min. 95%