3',5'-Di-O-(tert-butyldimethylsilyl)-2'-deoxy-N2-DMF-guanosine

CAS: 501930-40-1

Ref. 3D-NB181729

Product Information

• Name: 3',5'-Di-O-(tert-butyldimethylsilyl)-2'-deoxy-N2-DMF-guanosine
• Brand: Biosynth
• Description: 3',5'-Di-O-(tert-butyldimethylsilyl)-2'-deoxy-N2-DMF-guanosine is a phosphoramidite nucleoside that is synthesized by the reaction of 2'-deoxyguanosine and dimethyldichlorosilane. This product has anticancer activity, as it inhibits DNA synthesis and topoisomerase II activity. It also has antiviral effects, as it inhibits viral RNA synthesis. 3',5'-Di-O-(tert-butyldimethylsilyl)-2'-deoxy-N2-DMF-guanosine has been shown to be more stable than its corresponding 5'-di-O-(tert-butyldimethylsilyl) analogue, with a half life of greater than 10 hours in phosphate buffered saline at 37°C.

Chemical properties

• Molecular weight: 550.84 g/mol
• Formula: C₂₅H₄₆N₆O₄Si₂
• Purity: Min. 95%
• Color/Form: Powder