2'-O-tert-Butyldimethylsilyluridine

CAS: 54925-71-2

Ref. 3D-NB46819

Product Information

• Name: 2'-O-tert-Butyldimethylsilyluridine
• Synonyms: 2'-TBDMS-rU
• Brand: Biosynth
• Description: 2'-O-tert-Butyldimethylsilyluridine is a nucleoside that is used in DNA synthesis, antiviral research, and anticancer therapy. It is synthesized from 2'-deoxyuridine monophosphate (2'-dUMP) with the aid of a phosphoramidite coupling agent. It has shown to be an effective activator in the synthesis of oligonucleotides, which are short chains of nucleotide units that can be used for various purposes including the treatment of cancer cells. These chains are synthesized by linking together individual nucleosides with phosphate molecules at each end. The bonds between these phosphate groups and the sugar-phosphate backbone of the nucleotide units are called phosphodiester bonds. This synthetic process can be used to produce DNA or RNA strands as well as modified versions of these strands such as those that have been synthesized with other chemical groups on their sugar-phosphate backbones.

Chemical properties

• Molecular weight: 358.46 g/mol
• Formula: C₁₅H₂₆N₂O₆Si
• Purity: Min. 95%
• Color/Form: Powder