6-Benzyl-2-thiouracil

CAS: 6336-50-1

Ref. 3D-NB67066

Product Information

• Name: 6-Benzyl-2-thiouracil
• Synonyms: 6-Benzyl-4-hydroxy-2-mercaptopyrimidine, 2,3-Dihydro-6-(phenylmethyl)-2-thioxo-4(1H)-pyrimidinone, 4(1H)-Pyrimidinone, 2,3-dihydro-6-(phenylmethyl)-2-thioxo-, 6-benzyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, Basdene, Bentiuracil, Betiuracil, NSC 39511, NSC 6508, Uracil, 6-benzyl-2-thio-, Zinc 08580452

Description

6-Benzyl-2-thiouracil (BTS) is a benzyl group with the chemical formula C12H8N2OS. It has been used as an anti-infective agent and has been shown to have a clinical relevance in treating hepatitis, cutaneous lesions, and inflammatory bowel disease. BTS is metabolized through oxidation of the benzyl group by cytochrome P450 enzymes. This active form has been shown to inhibit mitochondrial fatty acid synthesis, which may be a pathogenic mechanism for BTS in women with metabolic syndrome. The metabolism of BTS also results in its conversion to 2-benzylpyrimidine, which can be converted into a carcinogen by N-nitrosation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 218.28 g/mol
• Formula: C₁₁H₁₀N₂OS
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C11H10N2OS/c14-10-7-9(12-11(15)13-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,12,13,14,15)
• InChI key: InChIKey=PNXBXCRWXNESOV-UHFFFAOYSA-N
• SMILES: O=c1cc(Cc2ccccc2)[nH]c(=S)[nH]1