8-Chloroadenosine
CAS: 34408-14-5
Ref. 3D-NC03343
| 5mg | 159.00 € | ||
| 10mg | 238.00 € | ||
| 25mg | 357.00 € | ||
| 50mg | 497.00 € | ||
| 100mg | 758.00 € |
Product Information
- 8-Chloro-D-adenosine
8-Chloroadenosine is a potent inhibitor of apoptosis, which is the process by which cells die. It has been shown to inhibit cell growth in murine hepatoma cells and synergize with other cytotoxic agents. 8-Chloroadenosine inhibits the activity of bcl-2 protein and thus blocks the release of cytochrome c from mitochondria. This causes DNA damage by inhibiting DNA synthesis and protein synthesis, leading to apoptosis. 8-Chloroadenosine has also been shown to be an active inhibitor of cancer cells, especially myeloma cell lines. The response element for 8-chloroadenosine is located in the promoter region of the gene encoding cyclooxygenase 2 (COX-2), which encodes a protein that produces prostaglandins involved in inflammation and tumor growth. The concentration of camp in cancer tissues determines whether these cells will respond favorably or unfavorably to this drug.
Chemical properties
Technical inquiry about: 3D-NC03343 8-Chloroadenosine
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