5-Chloro-2'-deoxyuridine

CAS: 50-90-8

Ref. 3D-NC04688

Product Information

• Name: 5-Chloro-2'-deoxyuridine
• Synonyms: 5-Chloro-2'-deoxy-D-uridineCldU
• Brand: Biosynth
• Description: 5-Chloro-2'-deoxyuridine is a nucleoside analog that inhibits DNA synthesis by inhibiting the enzyme thymidylate synthetase. It has been used for the treatment of bladder cancer and may also be beneficial in treating other cancers such as colon cancer. 5-Chloro-2'-deoxyuridine is taken up from the intestine by cells, where it is converted to thymidine monophosphate and then to thymidine diphosphate, which inhibits DNA synthesis by interfering with cell division. The mechanism of action is similar to that of cytosine arabinoside, but it does not require activation by intracellular enzymes. 5-Chloro-2'-deoxyuridine can cause cell lysis and can inhibit protease activity during cell culture, which makes it a useful tool for purifying proteins or peptides. The drug has been shown to be an analog of cytosine arabinos

Chemical properties

• Molecular weight: 262.65 g/mol
• Formula: C₉H₁₁ClN₂O₅
• Purity: Min. 98 Area-%
• Color/Form: White Powder