Gemcitabine 5'-elaidate

CAS: 210829-30-4

Ref. 3D-NC05399

Product Information

• Name: Gemcitabine 5'-elaidate
• Synonyms: (E)-((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate2'-Deoxy-2',2 '-difluorocytidine 5'-(9E)-9-octadecenoateCP-4126LVT derivative of GemcitabineCO-101
• Brand: Biosynth
• Description: Gemcitabine 5'-elaidate is an analog of gemcitabine that has hydrophobic properties. It has been shown to be active against solid tumours, including lung cancer. In a study on murine xenografts, gemcitabine 5'-elaidate was found to have the same degree of efficacy as gemcitabine in reducing tumour growth and increasing survival time. Gemcitabine 5'-elaidate also has good antitumour activity against infectious diseases such as HIV and malaria, which may be due to its ability to bind to the epidermal growth factor receptor (EGFR) on the surface of cells. This binding prevents EGFR from initiating cellular signaling.

Chemical properties

• Molecular weight: 527.66 g/mol
• Formula: C₂₇H₄₃F₂N₃O₅
• Purity: Min. 95%