2-Chloroadenosine

CAS: 146-77-0

Ref. 3D-NC06293

Product Information

• Name: 2-Chloroadenosine
• Synonyms: 6-Amino-2-chloropurine riboside2-Chloro-D-adenosine2-CADO, 2-Chloradenosinhemihydrat, 2-Chloro-<span class="text-smallcaps">D</span>-adenosine, 2-Chloro-D-adenosine, 2-Chloroadenosine, hemihydrate, 2-Chloroadenosinehemihydrate, 2-Cloroadenosina, Hemihidrato, Antibiotic AT 265B, Cado, Nsc 36896, 6-amino-2-chloropurine riboside, Adenosine, 2-chloro-, 2-chloro-9-pentofuranosyl-9H-purin-6-amine

Description

2-Chloroadenosine is a p-hydroxybenzoic acid derivative that belongs to the group of pharmacological agents. It has been shown to inhibit neuronal death in a model system by inhibiting adenosine receptor activity and decreasing the 2-chloroadenosine concentration. 2-Chloroadenosine has also been shown to reduce the production of proinflammatory cytokines, such as tumor necrosis factor alpha (TNFα) and interleukin 1beta (IL1β). This drug may be useful for the treatment of inflammatory diseases, such as asthma or rheumatoid arthritis. 2-Chloroadenosine also inhibits toll-like receptor 4 (TLR4), which is involved in the inflammatory response. The effect on TLR4 was shown by an inhibition of hydrogen fluoride-induced polymorphonuclear leucocyte activation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 301.69 g/mol
• Formula: C₁₀H₁₂ClN₅O₄
• Purity: Min. 95%
• Color/Form: Powder