Clevudine

CAS: 163252-36-6

Ref. 3D-NC09470

Product Information

• Name: Clevudine
• Synonyms: Levovir2'-Deoxy-2'-fluoro-5-methylarabinofuranosyluracil1-(2'-Deoxy-2'-fluoro-β-L-arabinofuranosyl)-5-methyluracil, 1-(2-Deoxy-2-fluoro-b-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione, 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione, 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione, 1-(2′-Deoxy-2′-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyluracil, 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil, 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-, 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-, L-Fmau, Levovir

Description

Clevudine is a nucleoside analogue reverse transcriptase inhibitor that is used in the treatment of chronic hepatitis B. Clevudine inhibits viral replication by interfering with the synthesis of viral DNA, thereby suppressing viral replication. In vitro studies have shown that clevudine prevents the development of resistant mutants. Studies in vivo have shown that clevudine can inhibit tumor growth when administered at low doses as an anti-cancer compound. Clevudine has been shown to be effective against polymerase chain reaction (PCR)-resistant strains of HIV-1 and reduces the production of interferon alpha-2b, which may be associated with its antiviral activity. The mechanism by which clevudine exerts its antiviral activity is not yet fully understood.

• Brand: Biosynth

Chemical properties

• Molecular weight: 260.22 g/mol
• Formula: C₁₀H₁₃FN₂O₅
• Purity: Min. 95%
• Color/Form: White Powder