Product Information
Name:5-Carboxyhydroxymethyluridine
Synonyms:
- 1,2,3,4-Tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetic acid
Brand:Biosynth
Description:5-Carboxyhydroxymethyluridine is a hydroxylated nucleoside that is used to study DNA repair. It is a nucleotide analogue that has been modified at the hydroxyl group by methylation. 5-Carboxyhydroxymethyluridine can be converted back to uridine by escherichia coli hydroxylases, but this conversion does not occur in vivo. 5-Carboxyhydroxymethyluridine can be used as a substrate for methyltransferase enzymes, which are involved in DNA repair. The enzyme 5'-methylthioadenosine phosphorylase converts 5-carboxyhydroxymethyluridine into S-adenosylhomocysteine and adenine. This conversion can be reversed by the enzyme methionine synthase. Some homologues of 5-carboxyhydroxymethyluridine have been found in nature and other modifications have been made on the
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Chemical properties
Molecular weight:318.24 g/mol
Formula:C11H14N2O9
Purity:Min. 95%
Color/Form:Powder
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