5-Cyanouridine
CAS: 4425-57-4
Ref. 3D-NC162899
| 5mg | 172.00 € | ||
| 10mg | 248.00 € | ||
| 25mg | 363.00 € | ||
| 50mg | 452.00 € | ||
| 100mg | 741.00 € |
Product Information
- 5-Pyrimidinecarbonitrile, 1,2,3,4-tetrahydro-2,4-dioxo-1-β-D-ribofuranosyl-
- Uridine, 5-cyano-
5-Cyanouridine is a pyrimidine nucleoside that is synthesized from uracil. It is a potent inhibitor of the enzyme decarboxylase, which catalyzes the conversion of 5-cytosine to 5-uracil, and has been used for the treatment of malignant lymphoma. 5-Cyanouridine is also a substrate for DNA replication and can be used as a target for antiviral drugs. The drug inhibits viral RNA synthesis by acting on the vesicular stomatitis virus (VSV) in two different ways: first, by inhibiting viral RNA polymerase activity; second, by incorporation into viral DNA. This incorporation can lead to chain termination or to translesion synthesis. 5-Cyanouridine has been shown to inhibit VSV replication in cell culture at concentrations as low as 1 μM.
Chemical properties
Technical inquiry about: 3D-NC162899 5-Cyanouridine
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