2'-Deoxy-5-fluorouridine

CAS: 50-91-9

Ref. 3D-ND02921

Product Information

• Name: 2'-Deoxy-5-fluorouridine
• Synonyms: 5-Fluoro-2'-deoxy-D-uridineFloxuridine2'-Deoxy-5-fluoro-D-uridine5-Fluoro-2'-deoxyuridine, (+)-5-Fluorodeoxyuridine, 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-fluorouracil, 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil, 1-(2-deoxy-D-threo-pentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione, 1-(2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione, 2-Deoxy-5-fluorouridine, 5-Fluoro-2'-deoxy-β-uridine, 5-Fluoro-2?Deoxy Uridine, 5-Fluorouracil 2'-deoxyriboside, 5-Fluorouracil deoxyriboside, 5-Fudr, Deoxyfluorouridine, FdUrd, Floxiridina, Floxuridin, Floxuridine, Fudr, Nsc 26740, Nsc 27640, Uridine, 2'-deoxy-5-fluoro-

Description

2'-Deoxy-5-fluorouridine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA. It has been shown to inhibit the growth of cancer cells and induce apoptosis in vivo. 2'-Deoxy-5-fluorouridine has also been shown to inhibit tumor growth in animal models by inhibiting the production of reactive oxygen species and upregulating tumor suppressor genes, such as p53. This drug also has inhibitory effects on enzymes that are involved in cell proliferation, such as protein kinase C and tyrosine kinases. 2'-Deoxy-5-fluorouridine is metabolized by water vapor, so it must be administered with a humidifier or nebulizer. 2'-Deoxy-5-fluorouridine may cause side effects such as nausea, vomiting, and diarrhea.

• Brand: Biosynth

Chemical properties

• Molecular weight: 246.2 g/mol
• Formula: C₉H₁₁FN₂O₅
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder