2'-Deoxy-L-adenosine

CAS: 14365-45-8

Ref. 3D-ND04246

Product Information

• Name: 2'-Deoxy-L-adenosine
• Synonyms: 9-(2-Deoxy-b-L-erythro-pentofuranosyl)adenine, 9-(2-deoxy-beta-L-threo-pentofuranosyl)-9H-purin-6-amine

Description

2'-Deoxy-L-adenosine is an adenosine analogue that has been shown to inhibit the growth of tumor cells in mice. The mechanism of this inhibition is not well understood, but it is thought that 2'-deoxy-L-adenosine inhibits the adenosine A3 receptor and blocks the activation of toll-like receptors. This drug also has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. It has been used as a model system for studying cellular responses to DNA damage caused by ultraviolet radiation. 2'-Deoxy-L-adenosine also has been shown to have a cytotoxic effect on human HL60 cells, which is mediated by nuclear DNA fragmentation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 251.25 g/mol
• Formula: C₁₀H₁₃N₅O₃
• Purity: Min. 98 Area-%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7-/m1/s1
• InChI key: InChIKey=OLXZPDWKRNYJJZ-DSYKOEDSSA-N
• SMILES: Nc1ncnc2c1ncn2[C@H]1C[C@@H](O)[C@H](CO)O1