3-Deazaadenosine

CAS: 6736-58-9

Ref. 3D-ND04697

Product Information

• Name: 3-Deazaadenosine
• Synonyms: 4-Amino-1-β-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine3-Deaza-D-adenosine, 3dAdo, Adenosine, 3-deaza-, Deaza-Ado, Nsc 167897, 1H-Imidazo(4,5-c)pyridin-4-amine, 1-beta-D-ribofuranosyl-, 1H-Imidazo(4,5-c)pyridine, 4-amino-1-beta-D-ribofuranosyl-, 1-pentofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine, 1-(beta-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridin-4-amine

Description

3-Deazaadenosine is a methyltransferase inhibitor that has been shown to exhibit cytotoxicity against HL-60 cells and significant cytotoxicity against A549 cells. 3-Deazaadenosine inhibits the activity of matrix metalloproteinases (MMPs) such as MMP-9 in malignant brain tissue, which is a possible explanation for its anti-inflammatory properties. 3-Deazaadenosine also has inhibitory effects on the replication of DNA by binding to the enzyme DNA polymerase, which prevents transcription and replication. This drug also blocks the activity of topoisomerases, enzymes that maintain the integrity of bacterial DNA. It has been shown to have antimicrobial activity against bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica serovar Typhimurium. 3-Deazaadenosine is an experimental model for atherosclerosis because it can bind to divalent

• Brand: Biosynth

Chemical properties

• Molecular weight: 266.26 g/mol
• Formula: C₁₁H₁₄N₄O₄
• Purity: Min. 99 Area-%
• Color/Form: Powder