2'-Deoxy-5-propargyloxyuridine

CAS: 65367-85-3

Ref. 3D-ND08234

Product Information

• Name: 2'-Deoxy-5-propargyloxyuridine
• Synonyms: 2'-Deoxy-5-propargyloxy-D-uridine5-Propargyloxy-2'-deoxyuridine
• Brand: Biosynth
• Description: 2'-Deoxy-5-propargyloxyuridine is a synthetic compound that inhibits the herpes simplex virus by inhibiting thymidylate synthase, an enzyme in the synthesis of DNA. It is used to study the growth rate of herpes virus and has been shown to inhibit murine leukemia L1210 and human l1210 cells at concentrations of 10-20 μg/mL. 2'-Deoxy-5-propargyloxyuridine has also been shown to have inhibitory activities against other viruses, such as polio virus and influenza virus. 2'-Deoxy-5-propargyloxyuridine inhibits biosynthesis by binding to enzymes involved in the synthesis of nucleic acids. The inhibitory dose for this compound is not yet known, but it has been shown to have an inhibitory effect on cell culture when preincubated with cells before infection with herpes simplex virus.

Chemical properties

• Molecular weight: 282.26 g/mol
• Formula: C₁₂H₁₄N₂O₆
• Purity: Min. 95%
• Color/Form: Powder