3',5'-Di-O-benzoyl-2'-deoxy-2'-fluorouridine

Ref. 3D-ND08486

Product Information

• Name: 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluorouridine
• Synonyms: 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-D-uridine3',5'-Di-O-benzoyl-2'-fluoro-2'-deoxyuridine
• Brand: Biosynth
• Description: 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluorouridine is a novel nucleoside analog that has been shown to have anticancer activity in vitro. The compound is a monophosphate, which is synthesized from 2'-deoxyuridine and benzoyl chloride. 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluorouridine was found to have antiviral activity against herpes simplex virus type 1 (HSV1) and cytomegalovirus (CMV). It also inhibited the production of HIV in human lymphocytes. This nucleoside analog can be activated by phosphorylation at the 5' position to form a diphosphate, which inhibits DNA synthesis by incorporating into the growing DNA chain and preventing the movement of RNA polymerase along the template strand.

Chemical properties

• Molecular weight: 454.42 g/mol
• Formula: C₂₃H₁₉FN₂O₇
• Purity: Min. 95%