Product Information
- 5H-Pyrrolo[2,3-D]Pyrimidine
- 5H-Pyrrolo[2,3-d]pyrimidine (8CI)
7-Deazapurine is a cytostatic agent that inhibits the polymerase chain reaction by competitive inhibition of the incorporation of nucleotides into DNA. It has potent antitumor activity and significant cytotoxicity, which are due to its ability to inhibit DNA synthesis and cell division. 7-Deazapurine is also a nucleophilic compound that reacts with hydroxyl groups in DNA. The hydrolysis of 7-deazapurine by hydroxylases can be prevented by addition of high salt or trifluoroacetic acid, but this does not seem to affect its cytotoxic effects.
7-Deazapurine has been shown to have significant cytotoxicity against miapaca-2 cells and other cancer cell lines.
Chemical properties
Technical inquiry about: 3D-ND11318 7-Deazapurine
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