2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine
Ref. 3D-ND162842
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Product Information
2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine (2DFO) is a novel nucleoside analog that is phosphorylated to 2DFP, which is an antiviral drug that has been shown to inhibit the replication of HIV. 2DFO inhibits the activity of DNA polymerase, RNA polymerase, and reverse transcriptase, preventing the synthesis of viral DNA and RNA. This drug also inhibits the activity of human topoisomerase II alpha and beta, which are enzymes involved in replication and transcription. 2DFO binds to purine nucleosides by competitive inhibition at the enzyme active site, preventing the formation of ribonucleotides from deoxyribonucleosides.
Chemical properties
Technical inquiry about: 3D-ND162842 2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine
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