2'-Deoxy-5-iodouridine - EP

CAS: 54-42-2

Ref. 3D-ND172114

Product Information

• Name: 2'-Deoxy-5-iodouridine - EP
• Synonyms: 1-(2-Deoxy-b-D-ribofuranosyl)-5-iodouracilIdoxuridineDendrid, 1-(2-Dehydroxy-β-D-ribofuranosyl)-5-iodouracil, 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodouracil, 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil, 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione, 1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione, 1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-iodopyrimidine-2,4(1H,3H)-dione, 2'-Desoxy-5-iodouridine, 2-Deoxy-5-iodouridine, 5-Iodo-2'-Deoxy-D-Uridine, 5-Iodo-2'-desoxyuridine, 5-Iodo-deoxyuridine, 5-Iododeoxyuridine, 5-Iodouracil deoxyriboside, 5Iudr, Allergan 211, Dendrid, Emanil, Herpe-Gel, Herpesil, Herpidu, Herplex, IDU, Idexur, Idoxene, Idoxuridin, Idoxuridina, Idoxuridine, Idu Oculos, Iducher, Idulea, Idur, Iduridin, Iododeoxyuridine, Iudr, Joddeoxiuridin, Kerecid, Nsc 39661, Ophthalmadine, Skf 14287, Stoxil, Stoxip, Synmiol, Uridine, 2'-deoxy-5-iodo-, Virudox, 5-Iodo-2'-deoxyuridine

Description

2'-Deoxy-5-iodouridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. 2'-Deoxy-5-iodouridine has been shown to inhibit the growth of human HL60 cells in vitro at an optimum concentration of 20 μM. It also inhibits the replication of murine sarcoma virus at an optimum concentration of 16 μM.
2'-Deoxy-5-iodouridine has significant cytotoxicity against solid tumours in mice, which may be due to its ability to inhibit hydrogen fluoride (HF) induced lipid peroxidation and reduce glutathione levels.

• Brand: Biosynth

Chemical properties

• Molecular weight: 354.1 g/mol
• Formula: C₉H₁₁IN₂O₅
• Purity: Min. 95%
• Color/Form: Powder