2'-Deoxy-3,4,5,6-tetrahydrouridine
CAS: 31962-88-6
Ref. 3D-ND176541
| 1mg | 238.00 € | ||
| 2mg | 357.00 € | ||
| 5mg | 710.00 € | ||
| 10mg | 1,041.00 € | ||
| 25mg | 1,425.00 € |
Product Information
- 2(1H)-Pyrimidinone, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)tetrahydro-4-hydroxy-
2'-Deoxy-3,4,5,6-tetrahydrouridine (2DTHR) is a cytidine deaminase inhibitor that is used in vitro to inhibit the production of tumor necrosis factor (TNF). 2DTHR has been shown to be active against hepatocellular carcinoma cells. It is also reactive with tumor tissue and can be eliminated at a rate similar to that of deoxycytidine kinase. This drug binds to the enzyme target and inhibits its activity by increasing enzyme levels, which causes cell death. 2DTHR inhibits TNF production in tumor tissue by binding to cytidine deaminase and preventing conversion of cytidine into uracil. This drug has been shown to cause tumor inhibition in vitro.
Chemical properties
Technical inquiry about: 3D-ND176541 2'-Deoxy-3,4,5,6-tetrahydrouridine
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