5’-O-tert-Butyldimethylsilyl-2’,3’-O-isopropylideneuridinefuro[3,4-d]-1,3-dioxole

CAS: 102147-76-2

Ref. 3D-ND181575

Product Information

• Name: 5’-O-tert-Butyldimethylsilyl-2’,3’-O-isopropylideneuridinefuro[3,4-d]-1,3-dioxole
• Brand: Biosynth
• Description: 5’-O-tert-Butyldimethylsilyl-2’,3’-O-isopropylideneuridinefuro[3,4-d]-1,3-dioxole (TBDMS) is a novel antiviral and anticancer drug. TBDMS is a monophosphate nucleotide analog that binds to the viral RNA polymerase enzyme and blocks the synthesis of viral RNA. TBDMS has been shown to be active against herpes simplex virus type 1 (HSV) in vitro and in vivo with no toxicity to normal cells. It also has an inhibitory effect on myeloid leukemia cells. TBDMS is not active against human DNA polymerase α or β, which are involved in DNA replication.TBDMS is a high purity product with high quality and good solubility in water. It is soluble in DMSO at a concentration of 0.5 mg/mL at room

Chemical properties

• Molecular weight: 398.53 g/mol
• Formula: C₁₈H₃₀N₂O₆Si
• Purity: Min. 95%